How to Fill Out DEA Form 222
DEA Form 222 is the official record for ordering and transferring Schedule II controlled substances — including sending them to a reverse distributor for destruction. Here’s how to fill it out correctly, and the common mistakes to avoid.
In this guide
What DEA Form 222 is for
Form 222 documents a Schedule II transaction between DEA registrants — ordering, or transferring Schedule II drugs to a reverse distributor for destruction. It creates the official chain-of-custody record. Many registrants now use the electronic CSOS equivalent.
How to complete Form 222
- Enter the supplier/recipient DEA registration details
- List each Schedule II drug, its size, and the number of packages
- Sign and date it as the authorized registrant
- Keep your copy; the other copies go with the transaction
- Retain the record for at least two years
Common mistakes
- Incomplete or mismatched registrant details
- Errors in package counts (no cross-outs allowed)
- Missing signatures
- Not retaining the copy for two years
When you use a DEA-registered reverse distributor, we prepare and guide the DEA Form 41 and Form 222 so it’s done right.
Let us handle the DEA paperwork.
We prepare Form 222 and Form 41 and render your controls non-retrievable — with a Certificate of Destruction, no contract.
Frequently asked questions
What is DEA Form 222 used for?
It documents ordering and transferring Schedule II controlled substances between DEA registrants — including transfers to a reverse distributor for destruction.
How do I fill out DEA Form 222?
Enter the registrant details, list each Schedule II drug with package sizes and counts, sign and date it, distribute the copies, and retain your copy for at least two years. No cross-outs are allowed.
Is there an electronic version of Form 222?
Yes — the DEA's Controlled Substance Ordering System (CSOS) is the electronic equivalent many registrants now use.
Can Easy Rx Cycle help with Form 222?
Yes — as a DEA-registered reverse distributor we prepare and guide Form 222 for Schedule II transfers, plus Form 41 for destruction.