Secure, Compliant Waste Disposal for 340B Pharmacies & Covered Entities

Why Proper Waste Disposal Is Critical for 340B Pharmacies

Because 340B pharmacies receive medications at discounted federal pricing, waste and destruction must be handled with extra care to ensure:

• Full compliance with DEA regulations for controlled substances

• Accurate documentation to maintain HRSA audit readiness

• Prevention of diversion or loss of inventory tied to 340B funding

• OSHA and DOT compliance for sharps and transport of regulated waste

Failure to properly dispose of 340B drugs can jeopardize:

• Program eligibility and HRSA compliance

• Covered entity status

• Accreditation or pharmacy licensure

• Reimbursement eligibility and contract renewals

Easy RX Cycle ensures that all disposal events are fully documented and aligned with federal compliance standards — protecting your program, patients, and funding.

What We Dispose Of for 340B Pharmacies

Expired and Unused Medications

• 340B inventory no longer usable or within expiration

• Non-controlled and controlled (Schedule II–V) medications

• Returned stock from patient delivery or clinics

• Recalled products and unusable inventory

DEA-Controlled Substances

• Schedule II–V medications requiring DEA Form 41

• Schedule I–II transfers using DEA Form 222

• Expired, discontinued, or partially used drugs

• Witnessed destruction and full documentation included

Sharps & Regulated Medical Waste

• Syringes, needles, and lancets used in immunization programs

• Biohazardous waste from compounding or medication prep

• PPE and disposables from pharmacy environments

Flexible Disposal Options for 340B Pharmacies

Mail-Back Kits

• DEA- and DOT-compliant containers (1–5 gallons)

• Accepts expired medications, sharps, and controlled substances

• Includes DEA Form 41 support

• Certificate of Destruction provided digitally

• Ideal for low-to-moderate waste volumes or contract pharmacies

Scheduled Pickup Services

• For larger 340B programs, health systems, or centralized pharmacies

• On-site removal of pharmaceutical and medical waste

• Chain-of-custody manifesting and Certificates of Destruction

• Recurring or as-needed scheduling based on inventory turnover

Who We Serve

We work with a range of 340B providers and contract pharmacy partners, including:

• Federally Qualified Health Centers (FQHCs)

• Critical Access Hospitals (CAHs)

• Ryan White HIV/AIDS Program clinics

• Disproportionate Share Hospitals (DSHs)

• Children’s hospitals and rural health clinics

• 340B contract pharmacies (retail and specialty)

• Tribal and urban Indian health programs

Whether you operate a small contract pharmacy or a multi-site 340B distribution hub, we provide compliant waste management tailored to your scale and reporting needs.

Compliance With DEA, HRSA, EPA, DOT & OSHA

Easy RX Cycle ensures every 340B pharmacy meets federal and state requirements, including:

• DEA 21 CFR Part 1317 – Controlled substance disposal

• DEA Form 41 & Form 222 – Documentation and witness coordination

• HRSA audit requirements for 340B inventory tracking and destruction

• EPA RCRA Subtitle C – Hazardous pharmaceutical waste compliance

• DOT 49 CFR Part 173 – Regulated waste transport

• OSHA 29 CFR 1910.1030 – Sharps and bloodborne pathogen standards

All services include full documentation and Certificates of Destruction — with audit support for both HRSA and DEA inspections.

Request a Quote Today!

Partner with us for safe, DEA-compliant disposal of your expired controlled substances. Our reverse distribution services are designed to save you time, ensure compliance, and protect your organization. Fill out our form to get a personalized quote and experience the ease of working with a trusted DEA-registered reverse distributor.